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== Introduction==
There are a number of methods which can be used to modify the crystallization behavior of proteins.
 
 
=== Genetic/Mutagenesis Approach===
There is a webserver, called SER (Surface Entropy Reduction Prediction Server), which aims to predict sites that are most suitable for mutation designed to enhance crystallizability:
httphttps://nihserverservices.mbi.ucla.edu/SER/intro.php
=== Chemical Modification===
A recent study (Walter et al. [2006] "Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization" Structure 14:1617–1622) demonstrated that, out of 10 non-crystallizable proteins,
4 proteins became crystallisable after reductive methylation.
 
Here is a protocol for [[Lysine Methylation]].
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