Microseeding

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Acta Cryst. (2010). D66, 927-933 (free access) Promoting crystallization of antibody-antigen complexes via microseed matrix screening G. Obmolova, T. J. Malia, A. Teplyakov, R. Sweet and G. L. Gilliland

Synopsis: The application of microseed matrix screening to the crystallization of related antibodies in complex with IL-13 is described. Both self-seeding or cross-seeding helped promote nucleation and increase the hit rate.