Recent Publications
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"KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry " Betz, K., Malyshev, D.A., Lavergne, T., Welte, W., Diederichs, K., Dwyer, T.J., Ordoukhanian, P., Romesberg, F.E. and Marx, A. Nature Chemical Biology Vol. 7(8), pp. 612-4 (2012)
Unnatural base pair formation induces conformational transitions of KlenTaq and the formation of a natural-like ternary complex. |
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"Linking crystallographic model and data quality" Karplus, P.A. and Diederichs, K. Science Vol. 336, pp. 1030-3 (2012)
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Image courtesy of P.A. Karplus. |
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Explanatory notes:
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"Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop " Eicher, T., Cha, H., Seeger, M., Brandstätter, L. El-Delik, J., Bohnert, J.A., Kern, W.V., Verrey, F., Grütter, M.G., Diederichs, K. and Pos, K.M. PNAS Vol. 109, pp. 5687-92 (2012)
Explanatory notes: Stepwise AcrB-catalyzed drug transport mediated by cycling between the Loose (blue), Tight (yellow), and Open (red) conformation within an AcrB trimer.
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