Protein Crystallography and Molecular Bioinformatics
University of Konstanz

Recent Publications

"Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex"

Krieg, S., Huché, F., Diederichs, K., Izadi-Pruneyre, N., Lecroisey, A., Wandersman, C., Delepelaire, P., Welte, W.

Proc. Nat. Acad. Sci. Vol. 106 pp. 1045-1050 (2009)

  [Keine Beschreibung eingegeben]

Link to PNAS:
Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex.



"Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB"

Seeger, M.A., Ballmoos, C.v., Eicher, T., Brandstätter, L., Verrey, F., Diederichs, K., Pos, K.M.

Nature Struct. Mol. Biol. 15, 199-205 (2008)

  [Keine Beschreibung eingegeben]
Figure legend:

Link to the PDF file:
Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.



"Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism"

Markus A. Seeger, André Schiefner, Thomas Eicher, François Verrey, Kay Diederichs, Klaas M. Pos

Science Vol. 313 pp. 1295-1298 (2006)


Figure legend: Visualization of tunnel (green) in the O monomer of AcrB

Links to the PDF files:

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.
Supporting Online Material